Development of new adeno-associated virus capsid variants for targeted gene delivery to human cardiomyocytes
Recombinant adeno-associated viruses (rAAVs) have emerged as one of the most promising gene therapy vectors that have been successfully used in pre-clinical models of heart disease.However, this has not translated well to humans due to species differences in rAAV transduction efficiency.As a result, the search for human cardiotropic capsids is a ma